Victory by two goals or more would see Latvia jump into third above Latvia before Serbia visit Albania in the evening kick-off.
England will stay top of the group if they avoid defeat, although a win would guarantee them top spot irrespective of what Albania do in their two matches this month.
Andorra have no fresh injury concerns to report with a full squad in contention.
England have a full squad available with James Trafford and Trevoh Chalobah both looking for their first senior international caps.
Andorra meet England at RCDE Stadium, Barcelona, Spain, on Saturday 7 June at 6pm CEST (5pm UK Time), live on ITV1 and ITVX in the UK.
The reason behind the game’s move to Barcelona is due to no venue in Andorra being suitable to host England.
With just two goals scored in one of their last ten matches, Andorra certainly need a huge defensive performance and a clinical end product to just try and snatch any point as this is simply a ‘throw everything at kitchen sink and hope for best’ type game.
England meanwhile are favourites but after two clinical yet uninspiring wins over Albania and Latvia in March, I now want to see more of Thomas Tuchel’s style come to the surface if they’re to challenge for the World Cup – as those two performances still felt Gareth Southgate like.
Andorra however does look like a team just there for the taking and with England’s quality, it is easy to expect a five-goal demolition at minimum but I expect them to make it harder than it should be despite getting the win.
Prediction: Andorra 0-3 England